Donald A. Ross, M.D.

Physician and Surgeon: Neurological and Spine Surgery

BIOGRAPHY

Dr. Ross graduated first in his class from the Indiana University School of Medicine. He did his residency in neurological surgery at the University of California, San Francisco and was a Fellow in Cranial Base Surgery at the University of Pittsburgh under Dr. Laligam Sekhar. He then joined the faculty of the University of Michigan Medical Center as an Assistant Professor of Surgery. His practice at the University of Michigan included cranial base surgery, epilepsy surgery, brain tumor surgery, and stereotactic radiosurgery. Dr. Ross developed a national and international reputation and was promoted to Associate Professor with tenure. In collaboration with the Otolaryngology Department, he established a multi-disciplinary cranial base program which did a large volume of craniofacial resections, orbital surgery, reconstruction after trauma, cavernous sinus surgery, temporal bone surgery, vestibular scwhannoma resections, and surgery at the foramen magnum. As a result of his close collaborations and successful programs he was given an additional Associate Professor appointment in the Otolaryngology Department. In collaboration with the Department of Radiation Oncology, Dr. Ross participated in the establishment of the University of Michigan Sterotactic Radiosurgery Program, the first program in the nation to utilize multi-leaf collimation in the radiosurgical treatment of cerebral arteriovenous malformations, vestibular scwhannomas, metastatic brain tumors, and recurrent gliomas.

As part of the University of Michigan Epilepsy Program, Dr. Ross performed over 450 epilepsy operations, including temporal lobectomy, corpus callosotomy, vagus nerve stimulation, and multiple subpial transactions. He has utilized techniques derived from epilepsy surgery, including awake craniotomy, functional cortical mapping, and frameless navigation to enhance the efficacy and safety of glioma surgery. As co-director of the Brain Tumor Research Laboratory, Dr. Ross ran an active basic science effort directed at the molecular genetics of malignant gliomas and the prevention of anaplastic transformation of low grade gliomas. Dr. Ross has authored over 90 peer reviewed papers and book chapters and holds a patent on a new surgical device. Dr. Ross joined Medford Neurological & Spine Clinic in 2000.

Dr. Ross’ special interests include cranial surgery, minimally invasive spine surgery and Radiosurgery.

Dr. Ross’ personal interests include music, reading, gardening and hiking.

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CURRICULUM VITAE

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BIBLIOGRAPHY

Completed Publications in Scientific Journals

Peer Reviewed Publications

1. Harkrader RJ, Jackson RC, Ross DA, Weber G: Increase in Liver and Kidney Deoxycytidine Kinase Activity Linked to Neoplastic Transformation. Biochemical and Biophysical Research Communications 96:1633-1639, 1980

2. Jackson RC, Ross DA, Harkrader RJ, Epstein J: Biochemical Approaches to Enhancement of Antitumor Drug Selectivity: Selective Protection of Cells from 6-Thioguanine and 6-Mercaptopurine by Adenosine. Cancer Treatment Reports 64:1347-1353, 1980

3. Ross DA, Jackson RC, Weber G: Decreased Content of Reduced and Oxidized Nicotinamide-Adenine Dinucleotide Phosphate in Rat Hepatomas. Cancer Biochem Biophys 6:61-64, 1982

4. Grosfeld JL, Kamman K, Gross K, Cikrit D, Ross DA, Wolfe M, Katz S, Weber TR: Comparative Effects of Indomethacin, Prostaglandin E1, and Ibuprofen on Bowel Ischemia. J Pediatric Surgery 18:738-742, 1983

5. Cikrit D, Gross K, Katz S, Plager D, Ross DA, Wolfe M, Weber T, Grosfeld J: Comparative Effects of Cytoprotective Agents on Bowel Ischemia. Surg Forum 34:208-210, 1983

6. Katz S, Grosfeld JL, Gross K, Plager DA, Ross DA, Rosenthal R, Hull M, Weber TR: Impaired Bacterial Clearance and Trapping in Obstructive Jaundice. Ann Surg 199:14-20, 1984

7. Jackson RC, Leopold WR, Ross DA: The Biochemical Pharmacology of (2'-R)-Chloropentostatin, A Novel Inhibitor of Adenosine Deaminase. Advances in Enzyme Regulation 25:125-139, 1986

8. Ross DA, Edwards MSB, Wilson CB: Intramedullary Neurilemomas of the Spinal Cord: Report of Two Cases and Review of the Literature. Neurosurgery 19:458-464, 1986

9. Ross DA, Walker J, Edwards MSB: Unusual Posterior Fossa Dural AVM in a Neonate: Case Report. Neurosurgery 19:1021-1024, 1986

10. Olsen WL, Winkler M, Ross DA: Carcinomatous encephalitis: CT and MR findings. Am J Neuroradiol 8:553-554, 1987

11. Floeter MK, So YT, Ross DA, Greenberg D: Miliary metastasis to the brain: Clinical and radiologic features. Neurology 37:1817-1818, 1987

12. Harsh GR IV, Sypert GW, Ross DA, Wilson CB, Weinstein P: Cervical spine stenosis secondary to ossification of the posterior longitudinal ligament: results of medial corpectomy and fusion in Americans. J Neurosurgery 67:349-357, 1987

13. Ross DA, Olsen WL, V. Halbach, Rosegay H, Pitts LH: Cervical root compression by a traumatic pseudoaneurysm of the vertebral artery: Case Report. Neurosurgery 22:414-417, 1988

14. Ross DA, Wilson CB: Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J Neurosurg 68:854-867, 1988

15. Ross DA, Rosegay H, Pons V: Postoperative aseptic meningitis in neurosurgical patients: A comparison with bacterial meningitis. J Neurosurg 69:669-674, 1988

16. Ross DA, Olsen W, Ross AM, Andrews B, Pitts L: Radiologic Evaluation of Brain Shift, Uncal Herniation, and Effacement of the Basal Cisterns in Relation to the Level of Consciousness in Patients with Acute, Unilateral Hemispheric Masses. J Neurosurg 71:498-502, 1989

17. Kalia K, Ross DA, Gutin PH: Multiple arterial fenestrations, multiple aneurysms, and an arteriovenous malformation in a patient with subarachnoid hemorrhage. Surgical Neurology 35:45-48, 1991

18. Ross DA, Drasner K, Weinstein PR, Flaherty JF, Barbaro NM: Use of intrathecal morphine in the treatment of postoperative pain after lumbar spine surgery: A prospective, double-blind, placebo-controlled study. Neurosurgery 28:700-704, 1991

19. Ross DA, Norman D, Davis R, Wilson CB: Rathke cleft cysts: Review of 43 cases. Neurosurgery 30:173-179, 1992

20. Sandler HM, Papadopoulos SM, Thornton AFJr, Ross DA: Spinal cord astrocytomas: Results of therapy. Neurosurgery 30:490-493, 1992

21. Ross DA: Use of modified pericranial flaps in anterior skull base reconstruction. Skull Base Surgery 2:83-86, 1992

22. Stern JD, Ross DA: Stereotactic management of benign pineal region cysts: Report of two cases. Neurosurgery 32:310-314, 1993

23. Ross DA: A simple stereotactic retractor for use with the Leksell stereotactic apparatus. Neurosurgery 32:475-476, 1993

24. Martell LA, Muraszko KM, Agrawal A, Ross DA: Efficacy of transferrin receptor-targeted immunotoxins in brain tumor cell lines and pediatric brain tumors. Cancer Research 53:1348-1353, 1993

25. Ross DA, McKeever P, Sandler H, Muraszko K: Myxopapillary ependymomas: Review of 14 cases and the results of nucleolar organizing region staining. Cancer 71:3114-8, 1993

26. Ross DA, Henry TR, Dickinson L: A percutaneous epidural screw electrode for the recording of intracranial EEG. Neurosurgery 33:332-334, 1993

27. Henry TR, Frey KA, Sackellares JC, Gilman S, Koeppe RA, Brunberg JA, Ross DA, Berent S, Buchtel HA, Young AB, Kuhl DE: In vivo cerebral metabolism and central benzodiazepine receptor binding in temporal lobe epilepsy. Neurology 43:1998-2006, 1993

28. Taren J, Ross DA, Gebarski SS: Stereotactic localization using fast spin-echo imaging in functional disorders. Acta Neurochir Suppl (Wein) 58:59-60, 1993

29. Ross DA, Muraszko KM, Dauser R: A special cyst puncture catheter for use in thick-walled or mobile intracranial cysts. Neurosurgery 34:191-192, 1994

30. Meyer J, Quint DJ, McKeever PE, Boland M, Ross DA: Giant Rathke cleft cyst. Am J Neuroradiol 15:533-636, 1994

31. Liang BC, Ross DA, Greenberg HS, Meltzer PS, Trent JM: Evidence of allelic imbalance of chromosome 6 in human astrocytomas. Neurology 44:533-536-1994

32. Brunberg JA, Frey KA, Horton JA, Deveikis JP, Ross DA, Koeppe RA: PET [15O] H2O Determination of Cerebral Blood Flow during Balloon Test Occlusion of the Internal Carotid Artery. Am J Neuroradiol 15:725-732, 1994

33. Doran SE, Henry TR, Bockenstedt PL, Ross DA: Uncomplicated stereotactic and open surgical procedures in patients with factor VII deficiency. Surgical Neurology 42:79-82, 1994

34. Polinsky M, McKeever PE, Telian S, Brunberg JA, Sandler H, Ross DA: Aggressive papillary middle ear tumor. Neurosurgery 35:493-497, 1994

35. Selwa LM, Berent S, Giordani B, Henry TR, Buchtel HA, Ross DA: Serial cognitive testing in temporal lobe epilepsy: Longitudinal changes with medical and surgical therapies. Epilepsia 35:743-749, 1994

36. Brunberg JA, Chenevert TL, McKeever PE, Ross DA, Junck LR, Muraszko KM, Dauser R, Pipe JG, Betley AT: In vivo determination of water diffusion coefficients and diffusion anisotropy: Correlation with structural alteration in astrocytomas of the cerebral hemispheres. AJNR 16:361-371, 1995

37. Pu AT, Sandler HM, Radany EH, Blaivas M, Page MA, Greenberg HS, Junck LR, Ross DA: Low grade gliomas: Preliminary analysis of failure patterns among patients treated using 3-D conformal external beam irradiation. Int J Radiat Oncol Biol Phys 31:461-466, 1995

38. Burdette DE, Sakurai SY, Henry TR, Ross DA, Pennell PB, Frey KA, Sackellares JC, Albin RL: Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. Neurology 45:934-941, 1995

39. Samra SK, Sneyd JR, Ross DA, Henry TR: Propofol effects on seizure and intracranially recorded epileptiform activity in partial epilepsy. Anesthesiology 82:843-851, 1995

40. Liang BC, Ross DA, Reed E: Genomic copy number changes of DNA repair genes ERCC1 and ERCC2 in human gliomas. JNeuroonc 26:17-23, 1995

41. Taren J, Ross DA, Lu Y, Harmon L: 3D laser scanning for image guided stereotactic neurosurgery. Acta Neurochir (suppl) 64:45-48, 1995

42. Cabbell K, Ross DA: Stereotactic microsurgical craniotomy for colloid cyst. Neurosurgery 38:301-307, 1996

43. Markert J, Chandler W, Ross DA: Extreme lateral approach to an A-V fistula of the ventral cervicomedullary junction. Neurosurgery 38:412-415, 1996

44. Ross DA, Brunberg JA, Drury I, Henry TR: The morbidity and efficacy of intracerebral depth electrode monitoring using magnetic resonance image-guided stereotactic surgery in partial epilepsy. Neurosurg 39:327-334, 1996

45. Kimmelman AC, Ross DA, Liang BC: Microsatellite instability of chromosome 10p in human gliomas. Genomics 34:250-254, 1996

46. Kim TA, Brunberg JA, Pearson JP, Wolf G, Ross DA: Solitary fibrous tumor of the paranasal sinuses: CT and MR appearance. AJNR 17:1767-1772, 1996

47. Drury I, Schuh L, Ross DA, Pennell P, Varma N, Henry T: Ictal patterns in temporal lobe epilepsy recorded by epidural screw electrodes. Electroencephalography & Clinical Neurophysiology 102:167-174, 1997

48. McKeever PE, Ross DA, Strawderman MS, Brunberg JA, Greenberg HS, Junck L: Comparison of prognostic information about gliomas provided by MIB-1, bromodeoxyuridine, and proliferating cell nuclear antigen with clinical parameters. J Neuropathol Exp Neurol 56:798-805, 1997

49. Huggins JE, Levine SP, Ross DA, Kushwaha RK, Schuh LA, Rohde MM, BeMent SL: Intraoperative recording of electrocorticogram for the development of a direct brain interface. Proc of RESNA 1997 Annual Conference, pp 552-554, 1997

50. Polinsky MN, Geer CP, Ross DA: Stereotaxy reduces cost of brain tumor resection. Surgical Neurol 48:542-550, 1997

51. Colon G, Quint DJ, Dickinson LD, Brunberg JA, Jamerson KA, Hoff JT , Ross DA: MR evaluation of ventrolateral medullary compression in essential hypertension. J Neurosurg 88:226-231, 1998

52. Colon G, Hoff JT, Ross DA: Serial craniotomy for hyperostosing meningioma. J Neurosurg 88:346-348, 1998

53. Liang BC, Hays L, Kish P, Ross DA: Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncology Reports 4:613-617, 1997

54. Ross DA, Sandler HM, Balter JM, Hornick D: Stereotactic Radiosurgery of a Patient with Severe Kyphosis: Technical note. J Radiosurgery 1:129-132, 1998.

55. Schuh LA, Henry TR, Fromes G, Blaivas M, Ross DA, Drury I: Influence of head trauma on outcome following anterior temporal lobectomy. Archives of Neurology 55:1325-1328, 1998

56. Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux A-M, Dutrillaux B, Ross DA, Malfoy B, Hanash S: GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. Oncogene 16:2997-3002, 1998

57. Ross DA, Kish P, Muraszko KM, Blaivas M, Strawderman M: Chemoprevention of Ethylnitrosourea-induced Rat Gliomas by Retinoic Acid. J Neurooncol 40:29-38, 1998

58. Pennell PB, Burdette DE, Ross DA, Henry TR, Albin RL, Sackellares JC, Frey KA: Muscarinic Receptor Loss and Preservation of Presynaptic Cholinergic Terminals in Mesial Temporal Sclerosis. Epilepsia 40:38-46, 1999

59. JM Balter, Ph.D., DL McShan, Ph.D., P. Archer, C.M.D., KM Forster, Ph.D., BA Fraass, Ph.D., D. Ross, M.D., HM Sandler, M.D., RK Ten Haken, Ph.D., MK Martel: Clinical implementation of radiosurgery using a multileaf collimator and a computer controlled radiotherapy system. Int J Rad Oncol Biol Phys (in press)

60. Archer PG, Balter JM, Sandler HM, Hayman JA, Ross DA: The treatment planning of segmental, conformal stereotactic radiosurgery utilizing a standard multi-leaf collimator. Med Dosimetry 24:13-19, 1999

61. Ross DA, Marentette LJ, Moore CE, Switz KL: Craniofacial resection: Decreased complication rate with a modified subcranial approach. Skull Base Surgery 9:95-100, 1999

62. Sheinberg MA, Ross DA: Cranial procedures without hair removal. Neurosurg 44:1263-1266, 1999

63. Kadoya C, Henry TR, Beydoun A, Ross DA, Domino EF: Middle latency auditory evoked potentials recorded from human temporal lobes and near the upper brainstem. In Hashimoto I, Kakigi K (eds): Recent Advances in Human Neurophysiology, Excerpta Medica, International Congress Series 1162, 1998, pp 256-264

64. Ross DA, Marentette LJ, Thompson BG, Haller JS: Use of hydroxyapatite bone cement to prevent cerebrospinal fluid leakage through the frontal sinus. Neurosurgery 45:401-403, 1999

65. Malow BA, Selwa LM, Ross DA, Aldrich MS: Lateralizing value of interictal spikes on overnight sleep-EEG studies in temporal lobe epilepsy. Epilepsia 40:1587-1592, 1999

66. Henry TR, Ross DA, Schuh LA, Drury I: Indications and outcome of ictal recording with intracerebral and subdural electrodes in refractory complex partial seizures. J Clin Neurophysiol 16:426-438, 1999

67. Kaur A, Harrigan M, McKeever PM, Ross DA: Adenoid cystic carcinoma metastatic to dura: Report of two cases. J Neurooncology 44:267-273, 1999

68. Malow BA, Bowes RJ, Ross DA: Relationship of temporal lobe seizures to sleep and arousal - a combined scalp-intracranial electrode study. Sleep 23(2):231-234, 2000

69. Levine SP, Huggins JE, Bement SL, Kushwaha RK, Schuh LA, Passaro EA, Rohde MM, Ross DA: Identification of electrocorticogram patterns as the basis for a direct brain interface. J Clin Neurophysiol 16:439-447, 1999

70. Huggins JE, Levine SP, BeMent SL, Kushwaha RK, Schuh LA, Rohde MM, Ross DA: Detection of event related potentials for development of a direct brain interface. J Clinical Neurophysiology 16:448-455, 1999

71. Clevens RA, Marentette LJ, Esclamado RM, Wolf GT, Ross DA: Incidence and management of tension pneumocephalus after craniofacial resection: case reports and review of the literature. Otolaryngology – Head & Neck Surgery 120:579-583, 1999

72. Moore CE, Ross DA, Marentette LJ: Critical pathways in anterior cranial base surgery. Otolaryngology – Head & Neck Surgery 121:113-118, 1999

73. Moore CE, Ross DA, Marentette LJ: Subcranial approach to tumors of the anterior cranial base: Analysis of current and traditional surgical techniques. Otolaryngology – Head & Neck Surgery 120:387-390, 1999

74. Schuh LA, Henry TR, Ross DA, Smith BJ, Elisevich K, Drury I: Initial spiking patterns recorded from temporal depth electrodes predicts good outcome following anterior temporal lobectomy. Epilepsia 41:316-319, 2000

75. Ross DA, Sandler HM, Balter JM, Hayman JA, Archer PG, Deveikis J, Auer DL: Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations Using a Multileaf Collimator and a Single Isocenter. Neurosurgery 47:123-130, 2000

76. Levine SP, Huggins JE, Spencer L. BeMent, Ramesh K. Kushwaha, Lori A. Schuh, Mitchell M. Rohde, Erasmo A. Passaro, Donald A. Ross, Kost V. Elisevich, Brien J. Smith: A Direct Brain Interface Based on Event-Related Potentials. IEEE Transactions on Rehabilitation Engineering Vol. 8:2 p. 180-185, 2000.

77. Gorelick J, Ross DA, Marentette L, Switz K: Sinonasal undifferentiated carcinoma. Neurosurgery 47:750-755, 2000

78. Kaur A, Selwa L, Fromes G, Ross DA: The incidence of persistent headache after supratentorial craniotomy. Neurosurgery 47:633-636, 2000

79. Henry TR, Drury I, Schuh LA, Ross DA: Increased secondary generalization of complex partial seizures following anterior temporal lobectomy. Neurology 26:1812-17, 2000

80. Kish PE, Blaivas M, Strawderman M, Karin Muraszko, Ross DA: Magnetic Resonance Imaging of Ethylnitrosourea-induced Rat Gliomas: Antiprogressional effects of Vitamin A. J Neurooncology 53:243-257, 2001

81. Beth A. Malow, Jonathan Edwards, Mary Marzec, Oren Sagher, Donald Ross, Gail Fromes: Vagus Nerve Stimulation Reduces Daytime Sleepiness in Epilepsy Patients. Neurology 57:879-884, 2001

82. Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek D, Israel M, Ross DA, Kish P, Hanash S: The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. Cancer Res 61:2162-8, 2001

83. Ross DA, Sandler HM, Balter JM, Hayman JA, Archer PG, Auer DL: Radiographic Changes After Stereotactic Radiosurgery of Primary and Secondary Malignant Brain Tumors. J Neurooncol 56:175-181, 2002

84. Ross DA, Byers C, Hall T: A novel approach to prevent repeated catheter migration in a patient with a baclofen pump. Arch Phys Med Rehab 86:1060-1, 2005

85. Mahesh, MB, Ross DA, Sagher, O: Utilization of multiplanar trajectory planning in the stereotactic placement of depth electrodes. Neurosurgery 60:272-276, 2007

86. Ross DA, Narus M, Nutt R: Control of medically refractory restless legs syndrome with intrathecal morphine: case report and technical note. Neurosurgery 62:263, 2008.

Articles Submitted for Publication

87. Ross DA, Sagher O, Yang L, Ross AM: Radical resection of adult low grade oligodendroglioma without adjuvant therapy: Results of a prospective protocol. JNeurooncology (submitted)

88. Ross DA: Recurrent cervical foraminal stenosis after minimally invasive posterior foraminotomy due to regeneration of the resected bone. Neurosurgery (submitted)

Chapters in Books

1. Boldrey EB, Pitts LH, Ross DA: Intracranial Aneurysms, in LW Way (ed): Current Surgical Diagnosis and Treatment. Appleton & Lange, Norwalk, Connecticut, 1988, pp769-772 (Updated 1991, 1993)

2. Ross DA, Wilson CB: Results of Transsphenoidal Resection of Growth Hormone-Secreting Pituitary Adenomas, in Acromegaly, Robbins RJ and Melmed S (eds), Plenum Publishing, 1987, pp229-239

3. Henry TR, Ross DA: University of Michigan Epilepsy Surgery Protocols, in Luders H (ed): Epilepsy Surgery, Raven Press, New York, 1991

4. Ross DA: The Molecular Genetics of Tumors of the Central Nervous System, in Crockard A, Hayward R, Hoff JT: Neurosurgery. The Scientific Basis of Clinical Practice. Blackwell, Oxford, 1992

5. Sekhar LN, Ross DA, Sen CN: Cavernous Sinus Neoplasms, in Sekhar L, Janecka I (eds) : Surgery of Cranial Base Tumors. Raven Press, New York, 1992

6. Ross DA: Vestibular Schwannomas, in Neurobase. Arbor Publishing, La Jolla, 1998-2009 (Digital format)

7. Cabbell K, Ross DA: Stereotaxic Microsurgical Craniotomy for the Treatment of Third Ventricular Colloid Cysts, in Rengachary SS (ed): Neurosurgical Operative Atlas, AANS, Park Ridge, Illinois, 1997, Vol. 6, pp251-256

8. Cabbell K, Ross DA: Stereotaxic Microsurgical Craniotomy for the Treatment of Third Ventricular Colloid Cysts, in Sekhar L: Techniques in Sekhar L, de Oliveira (eds): Cranial Microsurgery, Thieme, New York, 1999, pp306-329

9. Ross DA: Frame Based Stereotactic Craniotomy: Technique. Contemporary Neurosurgery 20, November, 1998

Non-Peer Reviewed Publications

1. Edwards MSB, Ross DA: Review of Packer RJ, Finlay JL: Medulloblastoma: Presentation, Diagnosis, and Management. Oncology 2:45-49, 1988

2. Ross DA, Henry TR, Brunberg JA: Technology and equipment review. Intracranial electrodes. J Clin Neurophysiol 9:305-313, 1992

3. Richards JS, Sonda P, Gaucher E, Kocan MJ, Ross DA: Applying critical pathways to neurosurgery patients of the University of Michigan Medical Center. The Quality Letter 5:8-10, 1993

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